Table 2.
Addition of Risk Markers to the FRS: Effect on Risk Prediction in White Men
| Markers Added to FRS Model |
Number Reclassified (%) | Net Number Reclassified Correctly (NRI, P value) |
AUC (P value)* | |
|---|---|---|---|---|
| 9p21.3 | 205 (13.7) | 25 | (0.021, 0.41) | 0.586 (0.35) |
| KIF6 | 309 (20.7) | 33 | (0.027, 0.32) | 0.596 (0.03) |
| CRP | 346 (23.1) | 10 | (-0.017, 0.61) | 0.595 (0.15) |
| CRP + 9p21.3 | 412 (27.6) | 56 | (0.029, 0.40) | 0.599 (0.09) |
| CRP + KIF6 | 466 (31.2) | 86 | (0.093, 0.008) | 0.608 (0.02) |
| 9p21.3 + KIF6 | 348 (23.3) | 40 | (0.041, 0.18) | 0.600 (0.03) |
| CRP + 9p21.3 + KIF6 | 495 (33.1) | 93 | (0.076, 0.04) | 0.612 (0.01) |
* P value for change in the AUC from the AUC of the FRS model (0.581)