Table 3.
Addition of Risk Markers to the FRS: Effect on Risk Prediction in White Women
| Markers Added to FRS Model | Number Reclassified (%) | Net Number Reclassified Correctly (NRI, P value) |
AUC (P value)* | |
|---|---|---|---|---|
| 9p21.3 | 222 (10.3) | -16 | (-0.018, 0.39) | 0.621 (0.57) |
| KIF6 | 72 (3.3) | 0 | (0.007, 0.61) | 0.618 (0.57) |
| CRP | 270 (12.5) | -10 | (-0.032, 0.19) | 0.617 (0.69) |
| CRP + 9p21.3 | 362 (16.8) | 20 | (0.007, 0.81) | 0.620 (0.81) |
| CRP + KIF6 | 276 (12.8) | -4 | (-0.029, 0.24) | 0.617 (0.67) |
| 9p21.3 + KIF6 | 246 (11.4) | -2 | (0.015, 0.52) | 0.620 (0.65) |
| CRP + 9p21.3 + KIF6 | 357 (16.6) | 3 | (-0.002, 0.95) | 0.620 (0.81) |
* P value for change in the AUC from the AUC of the FRS model (0.619)