Table 6.
Addition of Risk Markers to the FRS: Effect on Risk Prediction in Black Women
| Markers Added to FRS Model |
Number Reclassified (%) | Net Number Reclassified Correctly (NRI, P value) |
AUC (P value)* |
|---|---|---|---|
| 9p21 | 110 (27.2) | 12 (0.013, 0.89) | 0.734 (0.40) |
| KIF6 | 11 (2.7) | -1 (-0.023, 0.35) | 0.723 (0.94) |
| CRP | 31 (7.7) | 13 (0.016, 0.70) | 0.726 (0.63) |
| CRP + 9p21 | 118 (29.1) | 14 (0.039, 0.70) | 0.735 (0.39) |
| CRP + KIF6 | 33 (8.1) | 9 (0.025, 0.60) | 0.725 (0.83) |
| 9p21 + KIF6 | 113 (27.9) | 15 (0.042, 0.66) | 0.733 (0.46) |
| CRP + 9p21 + KIF6 | 119 (29.3) | 15 (0.002,0.99) | 0.734 (0.46) |
* P value for change in AUC from AUC of the FRS model (0.723)