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Swiss mouse neurovirulence of YF 17D viruses
| Inoculation |
Dose (log10 PFU) |
Mouse challenge % mortality (dead/tested) |
AST ± SD (days)b |
|---|---|---|---|
| Control a | - | 0 (0/30) | - |
| YF 17DD (vaccine) | 3.0 | 97 (29/30) | 10 ± 1.8 |
| YF17D/NS2B3/Tc | 3.0 | 27 (8/30)* | 12 ± 4.1 |
| YF17D/E200/Tc | 3.0 | 3 (1/30)* | 13 ± 0.0 |
a The mouse control group was inoculated with only Earle's 199 medium by the intracerebral route
b AST, Average Survival Time ± Standard Deviation (SD)
* P < 0.05, logrank test (Mantel-Cox) test
