Table 2.
Numbers of monocyte-derived cells immunopositive for COX1 and COX2 in different brain regions during SIV infection and antiretroviral treatment.
| Brain regionsa | Ctrl | SIV,−AIDS | SIV,+AIDS | SIV,+AIDS,+ddG |
|---|---|---|---|---|
| COX1 | ||||
| Frontal cortex | 21.8±3.2 | 22.4±2.5 | 49.6±8.4b | 35.1±5.1c |
| Parietal cortex | 20.8±1.9 | 19.7±3.8 | 53.4±5.8b | 33.5±3.5c |
| Occipital cortex | 19.5±2.5 | 21.6±3.1 | 47.4±6.7b | 30.6±4.2 |
| Striatum | 23.1±1.1 | 24.4±2.6 | 55.4±9.1b | 36.1±6.2c |
| Corpus callosum | 21.6±2.4 | 20.5±3.1 | 50.2±10.2b | 32.4±4.8c |
| COX2 | ||||
| Frontal cortex | 0 | 0.1 | 9.7±2.4b | 0.6±0.1c |
| Parietal cortex | 0 | 0 | 8.2±4.7b | 0.3±0.2 |
| Occipital cortex | 0 | 0 | 7.1±3.8b | 0.1±0.1 |
| Striatum | 0 | 0.2±0.1 | 11.2±5.3b | 1.8±0.7c |
| Corpus callosum | 0 | 0.1±0.1 | 8.8±4.1b | 1.1±0.4c |
Abbreviations: AIDS, acquired immunodeficiency syndrome; COX1/2, cyclooxygenase isotype-1/2; Ctrl, control; ddG, 6-chloro-2',3'-dideoxyguanosine; SIV, simian immunodeficiency virus.
a
Data expressed as mean number (± s.e.m.) of COX1- and COX2-positive cells per 0.1 mm2 area.
b
Statistically significant different as compared to the other animal groups for the same brain area (p<0.05).
c
Statistically significant different only as compared to Ctrl and SIV,-AIDS groups for the same brain area (p<0.05). ANOVA and the post-hoc Newman-Keuls Multiple Comparison Test are used to evaluate statistical differences.