Figure 4. Independent prognostic significance of the multigene classifiers adjusted for known clinical and pathologic prognostic factors.

A) Prognostic value of the 19-Gene expression profile adjusted for known prognostic factors by Cox Proportional Hazards Regression in the training and 1^st validation sets. B) Kaplan-Meier analysis for OS as a function of the 19-gene profile for homogeneous subsets of patients with optimal and suboptimal debulking status in the training set. C) The combination of optimal debulking and low-risk 19-gene profile was associated with a median OS of 119 months in the training set and not-yet-reached in the validation set, while the combination of suboptimal debulking and high-risk 19-gene profile was associated with a median OS of 23 months in the training set (HR = 7.3, 95% C.I. 3.4–13.5) and 21 months in the 1^st validation set (HR = 5.8, 95% C.I. 2.1–16).