Table 3. Multivariate Analysis in the 2nd Validation Set.
| 19-Gene Profile Adjusted for Age, Grade, Stage and Residual Disease* in 2nd Validation Set | ||
| Prognostic Factor | Univariate P Value | Multivariate P Value |
| Age | 0.035 (HR = 1.56) | 0.06 |
| Gradea | 0.452 | 0.96 |
| Stage | 0.267 | 0.205 |
| Grossly Visible vsNo Visible | 0.003 (HR = 2.32) | 0.008 (HR = 2.21) |
| Gene Profile (high/low risk) | 0.015 (HR = 1.65) | 0.03 (HR = 1.59) |
a
Grade 1 tumors were removed from this dataset (Table 1). If we also remove grade 2 tumors from the 2nd validation dataset (as grade 2 disease can also be considered low grade), the 19-gene profile was again associated with overall survival both in univariate (HR = 1.8, 95% C.I. 1.09–2.99) and multivariate analysis (HR = 1.91, 95% C.I. 1.13–3.26).