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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Bioorg Med Chem. 2011 Mar 1;19(7):2269–2281. doi: 10.1016/j.bmc.2011.02.030

Scheme 2.

Scheme 2

Reagents and conditions: (a) mCPBA, 7c, 1,4-dioxane, 0 °C to r.t., 3 hours; (b) Oxone®, 7c, MeOH, H2O and 1,4-dioxane, 0 °C to 70–75 0 °C, 1 h. then r.t., 4 h.