Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of hAChE-Induced Aggregation of Aβ1–40 by 2,4-disubstituted pyrimidines (7a, 7c, 7d, 7g, 7s, 7t, 8c and 9c)
| Compd | Inhibition at 100 μM ± SEM (%)a |
|---|---|
| 7a | NA |
| 7c | NA |
| 7d | 59.0 ± 2.9 |
| 7g | 26.7 ± 17.0 |
| 7s | 55.9 ± 6.3 |
| 7t | 44.1 ± 11.0 |
| 8c | NA |
| 9c | 38 ± 25 |
| Donepezil | 17.4 ± 8.1 |
| Propidium iodide | 84.9 ± 4.1 |
The values are the mean of two independent measurements each performed in triplicates, SEM = standard error of mean
NA = Not active
