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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Gastroenterology. 2011 Jan 13;140(4):1334–1344. doi: 10.1053/j.gastro.2011.01.001

Figure 5. AFC8-hu HSC/Hep mice develop liver fibrosis after HCV infection.

Figure 5

(A) Representative liver sections from AFC8/mock, AFC8-hu/mock, AFC8 (no transplant)/HCV, and three AFC8-hu/HCV mice were stained with Sirius Red/Fast Green (top panels) to visualize liver fibrosis. Liver sections were also stained with a mouse monoclonal antibody against human α-smooth muscle actin (αSMA, bottom panels) to visualize activated stellate cells. Human or murine specific gene expression of TIMP1 (B) and COL1A1 (C) in the liver was measured using species-specific PCR primers. Values shown are relative gene expression normalized to human or mouse GAPDH, respectively. Data represent mean ± s.e.m.