Table 2. HCV infection and liver pathology in AFC8-hu mice.

Mouse #	HCV	HCV particles inoculated	days p.i.a	Metavir scoreb	Viral load in liver tissue (×103 copies/ug RNA)c
1	PBS	none	80	0	n/d
2	PBS	none	110	0	n/d
87	PBS	none	110	1	n/d *1
3	HCV patient 1	∼9e5	110	1	n/d
4	HCV patient 1	∼9e5	110	1	n/d
110d	HCV patient 1	∼9e5	110	1	18 *5
136d,e	HCV patient 1	∼9e5	93	2	87 *6
137d,e	HCV patient 1	∼9e5	89	2	180 *8
138d	HCV patient 1	∼9e5	110	1	n/d *2
139d	HCV patient 1	∼9e5	80	1	n/d *3
108	HCV patient 1	∼9e5	32	3	164 *7
109	HCV patient 1	∼9e5	80	3	14 *4
116f	Human sera	none	62	1	n/d
117	Human sera	none	48	1	n/d
88*4	Human sera	none	97	1	n/d
89*4	Human sera	none	97	1	n/d
99*4	Human sera	none	69	1	n/d
110*4	Human sera	none	69	1	n/d
90*4	HCV patient 2	∼5e5	34	3	323
91*4	HCV patient 2	∼5e5	57	2	168
92*4	HCV patient 2	∼5e5	97	4	n/d
98*4	HCV patient 2	∼5e5	69	1	n/d
100*4	HCV patient 2	∼5e5	69	2	347
108*4	HCV patient 2	∼5e5	97	2	n/d

^amice sacrificed due to experimental endpoints or poor health on days post HCV injection.

^bdetermined by analysis of Sirius Red stained liver sections. 0 = no fibrosis; 1 = only portal fibrosis; 2 = portal fibrosis with few septa; 3 = numerous septa without cirrhosis; 4 = cirrhosis.

^cHCV viral load in the liver tissue. *(1-8) mouse # from figure 2a. n/d = not detectable.

^dAFC8 mice reconstituted with human adult hepatocytes.

^eMice found dead (analyzed between 12-24 hr after death) on the indicated days post infection.

^fMouse #116, a non-transgenic mouse.