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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neurobiol Dis. 2010 Nov 21;43(1):68–78. doi: 10.1016/j.nbd.2010.11.003

Figure 6. Caspase-cleaved beclin-1 co-localizes with both early and late tangle markers of the Alzheimer’s brain.

Figure 6

(A-C): Double-label immunofluorescence images using the PHF-1 antibody (red, A), BeclinCCP antibody (green, B), and the two images overlapped (C). (D-F): Double-label immunofluorescence images using BeclinCCP antibody (red, D), the early tau conformation marker, MC-1 (green, E) and the two images overlapped (F). Yellow, orange coloring represents areas where markers are overlapping, which in this case was evident (arrows, F). (G-I): Identical to (D-F) showing in this case the lack co-localization within a damaged astrocyte labeled with BeclinCCP antibody (arrowhead, I), whereas co-localization between the two antibodies was evident within an apparent tangle-bearing neuron (arrow, I). All scale bars represent 10 μm.