Table 1.

LRR, Neurexins and Neuroligins implicated in human neurological diseases.

Gene	Associated disease	Reference
LRRTM1	Schizophrenia	(Francks et al. 2007)
LRRTM3	Alzheimer’s disease (late onset)	(Majercak et al. 2006)
	ASD	(Liang et al. 2007)
		(Sousa et al. 2010)
Neurexin1	ASD	(Kim et al. 2008)
		(Szatmari et al. 2007)
Neuroligin1	ASD	(Glessner et al. 2009)
Neuroligin3	ASD	(Jamain et al. 2003)
		(Talebizadeh et al. 2006)
Neuroligin4X	ASD	(Jamain et al. 2003)
		(Pampanos et al. 2009)
		(Talebizadeh et al. 2006)
Neuroligin4Y	ASD	(Yan et al. 2008)
LGI1	Autosomal-dominant partial epilepsy with auditory features	(Kalachikov et al. 2002)
	Autosomal dominant lateral temporal epilepsy	(Morante-Redolat et al. 2002)
LRRN3	ASD	(Sousa et al. 2010)
LRFN5	ASD	(Wang et al. 2009)
LRRN1	Recessive non-syndromic mental retardation	(Higgins et al. 2004)
SLITRK1	Tourette’s syndrome	(Abelson et al. 2005)
SLITRK2	ASD	(Piton et al. 2010)
	Bipolar disorder	(Smith et al. 2009)