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. 2011 Feb 26;12(1):388–400. doi: 10.1208/s12249-011-9602-5

Table II.

Study of Kinetic Parameters by Fitting Release Data to Various Equations and Dissolution Efficiency

Sample no. Zero-order equation First-order equation Cube root law Higuchi’s equation Korsmeyer–Peppas Dissolution efficiency
k 1 r 2 k 2 r 2 k 3 r 2 k 4 r 2 n a r 2 1 h 8 h
MIC1 1.7494 0.6409 0.0556 0.8167 0.057 0.7588 11.494 0.8187 0.2616 0.9292 42.49 56.61
MIC2 1.8574 0.932 0.0357 0.9845 0.044 0.9723 11.288 0.9948 0.3476 0.9953 23.01 32.31
MIC3 1.8193 0.7799 0.047 0.9284 0.0528 0.8874 12.078 0.902 0.2898 0.9412 36.14 47.35
MIC4 1.9433 0.8112 0.0538 0.9418 0.0585 0.9036 12.389 0.9527 0.2823 0.99 35.76 48.6
MIC5 2.4017 0.812 0.1151 0.9987 0.1002 0.968 15.319 0.9546 0.3025 0.9911 39.78 55.19
MIC6 2.0892 0.5987 0.2816b 0.9902 0.2178 0.7962 14.292 0.8096 0.2544 0.9342 50.41 69.49
MIC7 2.0115 0.9061 0.0512 0.9879 0.0573 0.9696 14.517 0.9837 0.2929 0.9954 32.36 43.4
MIC8 2.2184 0.7672 0.0717 0.9212 0.0736 0.8746 14.354 0.9281 0.3111 0.9821 35.28 51.53
MIC9 2.2952 0.7576 0.2805c 0.9757 0.1904 0.9535 11.343 0.868 0.1471 0.9337 68.76 80.4
MIC10 1.9395 0.9023 0.0433 0.9764 0.0508 0.9566 11.958 0.9911 0.3082 0.995 28.38 39.39
MIC11 1.9512 0.9262 0.0512 0.9929 0.0567 0.9797 11.892 0.9941 0.2707 0.99 34.58 44.67
MIC12 2.2355 0.8641 0.3689 0.9921 0.2281 0.9864 9.5615 0.9449 0.1017 0.9876 78.08 93.42

aExponent “n” of Korsmeyer–Peppas equation is obtained from slope of the profile

bCalculated with data up to t = 12 h

cCalculated with data up to t = 11 h