Table II.
Study of Kinetic Parameters by Fitting Release Data to Various Equations and Dissolution Efficiency
Sample no. | Zero-order equation | First-order equation | Cube root law | Higuchi’s equation | Korsmeyer–Peppas | Dissolution efficiency | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
k 1 | r 2 | k 2 | r 2 | k 3 | r 2 | k 4 | r 2 | n a | r 2 | 1 h | 8 h | |
MIC1 | 1.7494 | 0.6409 | 0.0556 | 0.8167 | 0.057 | 0.7588 | 11.494 | 0.8187 | 0.2616 | 0.9292 | 42.49 | 56.61 |
MIC2 | 1.8574 | 0.932 | 0.0357 | 0.9845 | 0.044 | 0.9723 | 11.288 | 0.9948 | 0.3476 | 0.9953 | 23.01 | 32.31 |
MIC3 | 1.8193 | 0.7799 | 0.047 | 0.9284 | 0.0528 | 0.8874 | 12.078 | 0.902 | 0.2898 | 0.9412 | 36.14 | 47.35 |
MIC4 | 1.9433 | 0.8112 | 0.0538 | 0.9418 | 0.0585 | 0.9036 | 12.389 | 0.9527 | 0.2823 | 0.99 | 35.76 | 48.6 |
MIC5 | 2.4017 | 0.812 | 0.1151 | 0.9987 | 0.1002 | 0.968 | 15.319 | 0.9546 | 0.3025 | 0.9911 | 39.78 | 55.19 |
MIC6 | 2.0892 | 0.5987 | 0.2816b | 0.9902 | 0.2178 | 0.7962 | 14.292 | 0.8096 | 0.2544 | 0.9342 | 50.41 | 69.49 |
MIC7 | 2.0115 | 0.9061 | 0.0512 | 0.9879 | 0.0573 | 0.9696 | 14.517 | 0.9837 | 0.2929 | 0.9954 | 32.36 | 43.4 |
MIC8 | 2.2184 | 0.7672 | 0.0717 | 0.9212 | 0.0736 | 0.8746 | 14.354 | 0.9281 | 0.3111 | 0.9821 | 35.28 | 51.53 |
MIC9 | 2.2952 | 0.7576 | 0.2805c | 0.9757 | 0.1904 | 0.9535 | 11.343 | 0.868 | 0.1471 | 0.9337 | 68.76 | 80.4 |
MIC10 | 1.9395 | 0.9023 | 0.0433 | 0.9764 | 0.0508 | 0.9566 | 11.958 | 0.9911 | 0.3082 | 0.995 | 28.38 | 39.39 |
MIC11 | 1.9512 | 0.9262 | 0.0512 | 0.9929 | 0.0567 | 0.9797 | 11.892 | 0.9941 | 0.2707 | 0.99 | 34.58 | 44.67 |
MIC12 | 2.2355 | 0.8641 | 0.3689 | 0.9921 | 0.2281 | 0.9864 | 9.5615 | 0.9449 | 0.1017 | 0.9876 | 78.08 | 93.42 |
aExponent “n” of Korsmeyer–Peppas equation is obtained from slope of the profile
bCalculated with data up to t = 12 h
cCalculated with data up to t = 11 h