Table III.
Characterization of Cellulose Microspheres Containing Pure Prednisolone (PRD; MIC1 and MIC2) and Complex (PRD–HPβCD, MIC3–12)
| Code no. | Percentage yield | Drug content (mg) | Entrapment efficiency (%) | Drug loading (%) | Total loss (mg) | Average particle size (μm) |
|---|---|---|---|---|---|---|
| MIC1 | 77.72 ± 1.625 | 83.15 ± 1.973 | 83.15 ± 1.973 | 21.4 ± 0.832 | 84.21 ± 9.867 | 139.25 ± 3.981 |
| MIC2 | 76.84 ± 2.798 | 80.94 ± 2.718 | 80.94 ± 2.718 | 26.33 ± 0.133 | 76.23 ± 10.874 | 168.93 ± 7.781 |
| MIC3 | 73.56 ± 2.812 | 32.68 ± 1.265 | 65.37 ± 2.53 | 7.16 ± 0.133 | 69.24 ± 5.06 | 361.51 ± 46.412 |
| MIC4 | 75.81 ± 3.357 | 34.39 ± 2.439 | 68.79 ± 4.879 | 6.78 ± 0.581 | 70.2 ± 10.978 | 412.28 ± 15.108 |
| MIC5 | 78.31 ± 2.39 | 37.77 ± 1.084 | 75.54 ± 2.168 | 6.7 ± 0.352 | 61.13 ± 5.421 | 422.27 ± 9.779 |
| MIC6 | 78.95 ± 2.337 | 38.38 ± 1.203 | 76.77 ± 2.406 | 6.32 ± 0.352 | 63.87 ± 6.616 | 437.87 ± 39.609 |
| MIC7 | 78.86 ± 1.475 | 36.94 ± 1.463 | 73.89 ± 2.927 | 6.08 ± 0.352 | 71.77 ± 8.05 | 443.42 ± 12.214 |
| MIC8 | 79.83 ± 2.198 | 38.8 ± 0.988 | 77.67 ± 1.976 | 5.93 ± 0.23 | 66.98 ± 5.928 | 449.17 ± 7.812 |
| MIC9 | 79.9 ± 1.66 | 40.32 ± 2.277 | 80.64 ± 4.554 | 7.01 ± 0.48 | 48.38 ± 11.387 | 308.66 ± 4.091 |
| MIC10 | 80.81 ± 1.916 | 35.18 ± 2.454 | 70.36 ± 4.909 | 5.01 ± 0.461 | 96.29 ± 15.954 | 465.71 ± 12.937 |
| MIC11 | 81.88 ± 1.136 | 37.16 ± 1.755 | 74.32 ± 3.51 | 4.93 ± 0.266 | 89.84 ± 12.286 | 470.94 ± 25.545 |
| MIC12 | 82.43 ± 1.816 | 40.9 ± 1.415 | 81.8 ± 2.83 | 5.39 ± 0.266 | 63.68 ± 9.908 | 340.16 ± 20.719 |
Data are the means of at least three experiments ± SD (p < 0.05). Yield is calculated with respect to the total weight of solid dispersion (320 mg of PRD–HPβCD complex) and polymers