Table I.
CTZ/Excipients | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(%) | ||||||||||||||||||||
CTZa | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 | 20.0 |
Avicel 102 | 50.0 | 48.5 | 46.0 | 41.0 | 50.0 | 48.5 | 46.0 | 41.0 | 50.0 | 48.5 | 46.0 | 41.0 | 50.0 | 48.5 | 46.0 | 41.0 | 50.0 | 48.5 | 46.0 | 41.0 |
XL10 | 2.0 | 5.0 | 10.0 | 20.0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vivasol | – | – | – | – | 2.0 | 5.0 | 10.0 | 20.0 | ||||||||||||
XL | – | – | – | – | – | – | – | – | 2.0 | 5.0 | 10.0 | 20.0 | – | – | – | – | – | – | – | – |
SF | – | – | – | – | – | – | – | – | – | – | – | – | 2.0 | 5.0 | 10.0 | 20.0 | – | – | – | – |
L-HPC | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 2.0 | 5.0 | 10.0 | 20.0 |
Mannitol | 27.5 | 26.0 | 23.5 | 18.5 | 27.5 | 26.0 | 23.5 | 18.5 | 27.5 | 26.0 | 23.5 | 18.5 | 27.5 | 26.0 | 23.5 | 18.5 | 27.5 | 26.0 | 23.5 | 18.5 |
Pruv | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
a CTZ coated granules