Table IV.
Fit of Various Model Equations (Eqs. 6, 7, 9, and 10) to Release Data for Tablets with a Single Release-Modifying Polymer
| Batch | k 1 | k 2 | k 3 | c | AIC |
|---|---|---|---|---|---|
| Higuchi | |||||
| PG1 | 0.237 ± 0.0138 | – | – | 0.503 ± 0.0190 | −27.70 |
| PG2 | 0.287 ± 0.0174 | – | – | 0.305 ± 0.0286 | −21.53 |
| PG3 | 0.318 ± 0.00501 | – | – | – | −33.49 |
| PK1 | 0.260 ± 0.0127 | – | – | – | −20.98 |
| PK2 | 0.260 ± 0.0112 | – | – | – | −22.62 |
| PK3 | 0.252 ± 0.0113 | – | – | – | −22.56 |
| PX1 | 0.221 ± 0.00365 | – | – | 0.0524 ± 0.00908 | −55.29 |
| PX2 | 0.217 ± 0.00218 | – | – | – | −56.50 |
| PX3 | 0.216 ± 0.00237 | – | – | −0.0397 ± 0.00590 | −60.22 |
| Peppas and Sahlin | |||||
| PG1 | 0.0991 ± 0.0394a | 0.0504 ± 0.0143a | – | 0.585 ± 0.0244 | −36.03 |
| PG2 | 0.268 ± 0.144a | 0.00601 ± 0.0451a | – | 0.318 ± 0.100a | −19.73 |
| PG3 | 0.318 ± 0.0229 | 1.71 × 10−10 ± 0.00964a | – | −31.49 | |
| PK1 | 0.143 ± 0.0190 | 0.0431 ± 0.00676 | – | – | −33.32 |
| PK2 | 0.161 ± 0.0216 | 0.0365 ± 0.00767 | – | – | −31.54 |
| PK3 | 0.150 ± 0.0194 | 0.0376 ± 0.00688 | – | – | −33.06 |
| PX1 | 0.221 ± 0.0201 | 3.093 × 10−12 ± 0.00424a | – | 0.0524 ± 0.0203 | −51.33 |
| PX2 | 0.208 ± 0.0169 | 8.56 × 10−11 ± 0.00436a | – | – | −37.48 |
| PX3 | 0.214 ± 0.0130 | 0.000467 ± 0.00275a | – | −0.0378 ± 0.0131 | −26.20 |
| Weibull | |||||
| PG1 | 0.0337 ± 0.00809 | – | – | 0.634 ± 0.00439 | −36.11 |
| PG2 | 0.0393 ± 0.00361 | – | – | 0.470 ± 0.0239 | −22.07 |
| PG3 | 0.0784 ± 0.00989 | – | – | – | −16.31 |
| PK1 | 0.0498 ± 0.00182 | – | – | – | −33.25 |
| PK2 | 0.0502 ± 0.00143 | – | – | – | −36.73 |
| PK3 | 0.0472 ± 0.00203 | – | – | – | −30.91 |
| PX1 | 0.0234 ± 0.00136 | – | – | 0.209 ± 0.0171 | −42.05 |
| PX2 | 0.0360 ± 0.00307 | – | – | – | −33.00 |
| PX3 | 0.0224 ± 0.00130 | – | – | 0.116 ± 0.0168 | −40.77 |
| Diffusion, relaxation, and erosion | |||||
| PG1 | 0.0682 ± 0.0527a | – | 0.0228 ± 0.00796a | 0.599 ± 0.00287 | −37.14 |
| PG2 | 0.264 ± 0.161a | – | 0.00240 ± 0.0162a | 0.320 ± 0.103a | −19.66 |
| PG3 | 0.318 ± 0.0229 | – | 5.700 × 10−11 ± 0.00321a | – | −31.49 |
| PK1 | 0.0733 ± 0.0269 | – | 0.00591 | – | −40.37 |
| PK2 | 0.0326 ± 0.0194a | – | 0.0403 ± 0.00542 | – | −37.80 |
| PK3 | 0.114 ± 0.0289 | – | 0.0202 ± 0.00517 | – | −35.20 |
| PX1 | 0.221 ± 0.0201 | – | 1.031 × 10−12 ± 0.00141a | 0.0524 ± 0.0203 | −51.33 |
| PX2 | 0.208 ± 0.0180 | – | 2.862 × 10−11 ± 0.00156a | – | −30.69 |
| PX3 | 0.214 ± 0.0131 | – | 0.000161 ± 0.000927a | −0.0377 ± 0.0132 | −58.32 |
a p > 0.05 and this coefficient is statistically insignificant. Therefore this model was not considered a candidate for the model that best fits the data