Table VI.

Fit of Various Model Equations (Eqs. 6, 7, 9, and 10) to Release Data for Tablets with Two Release-Modifying Polymers

Batch	k 1	k 2	k 3	AIC
Higuchi
PGK1	0.329 ± 0.0105	–	–	−22.10
PGK2	0.298 ± 0.00464	–	–	−23.63
PGK3	0.246 ± 0.00304	–	–	−40.95
PGX1	0.269 ± 0.00699	–	–	−29.28
PGX2	0.247 ± 0.00160	–	–	−49.94
PGX3	0.220 ± 0.00351	–	–	−38.94
PXK1	0.248 ± 0.00448	–	–	−29.50
PXK2	0.225 ± 0.00494	–	–	−32.25
PXK3	0.196 ± 0.00419	–	–	−32.35
Peppas and Sahlin
PGK1	0.329 ± 0.0747	2.11 × 10−10 ± 0.0298a	–	−20.10
PGK2	0.289 ± 0.0323	0.00351 ± 0.0129a	–	−22.32
PGK3	0.233 ± 0.0114	0.00494 ± 0.00404a	–	−40.49
PGX1	0.205 ± 0.0117	0.0234 ± 0.00416	–	−40.11
PGX2	0.238 ± 0.00565	0.00311 ± 0.00201a	–	−50.26
PGX3	0.220 ± 0.0147	6.954 × 10−11 ± 0.00522a	–	−36.94
PXK1	0.248 ± 0.0255	7.107 × 10−11 ± 0.00875a	–	−27.50
PXK2	0.218 ± 0.0210	0.00253 ± 0.00724a	–	−30.80
PXK3	0.196 ± 0.0239	4.574 × 10−11 ± 0.00819a	–	−30.35
Weibull
PGK1	0.0778 ± 0.00869	–	–	−21.76
PGK2	0.0621 ± 0.00532	–	–	−19.20
PGK3	0.0466 ± 0.00364	–	–	−22.57
PGX1	0.0532 ± 0.00342	–	–	−25.47
PGX2	0.0467 ± 0.00395	–	–	−21.46
PGX3	0.0386 ± 0.00393	–	–	−18.99
PXK1	0.0452 ± 0.00377	–	–	−23.78
PXK2	0.0400 ± 0.00459	–	–	−23.45
PXK3	0.0305 ± 0.00289	–	–	−23.24
Diffusion, relaxation, and erosion
PGK1	0.329 ± 0.0747	–	7.028 × 10−11 ± 0.00993a	−20.10
PGK2	0.288 ± 0.0329	–	0.00127 ± 0.00444a	−19.20
PGK3	0.232 ± 0.0117	–	0.00176 ± 0.00144a	−40.56
PGX1	0.198 ± 0.0142	–	0.00944 ± 0.00203	−40.39
PGX2	0.238 ± 0.00576	–	0.00107 ± 0.000696a	−50.33
PGX3	0.220 ± 0.0141	–	2.318 × 10−11 ± 0.00174a	−36.94
PXK1	0.248 ± 0.0255	–	2.369 × 10−11 ± 0.00292a	−27.50
PXK2	0.217 ± 0.0213	–	0.000893 ± 0.00250a	−30.75
PXK3	0.196 ± 0.0454	–	1.525 × 10−11 ± 0.00273a	−30.35

^a p > 0.05 and this coefficient is statistically insignificant. Therefore this model was not considered a candidate for the model that best fits the data