Table IV.

Aneuploidy rates of the IN-group (susceptible chromosome set) versus the OUT-group (remaining chromosomes) chromosomes

Chromosome group	≥10 p.p.m. benzene versus control					<10 p.p.m. benzene versus control
	OUTc-group		INc-group		P-value of interaction	OUT-group		IN-group		P-Value of Interaction
	IRRa	95% CIb	IRR	95% CI		IRR	95% CI	IRR	95% CI
Monosomy
5, 6, 7, 10, 12, 14, 16 and 19	1.09	0.75, 1.57	1.83	1.20, 2.82	<0.001	1.02	0.68, 1.52	1.33	0.85, 2.09	0.04
5, 6, 7, 10, 16 and 19	1.15	0.80, 1.65	2.00	1.22, 3.27	<0.001	1.06	0.71, 1.58	1.34	0.81, 2.22	0.18
5, 6, 7 and 10	1.21	0.84, 1.74	2.16	1.18 3.94	0.007	1.07	0.72, 1.60	1.48	0.83, 2.63	0.17
Trisomy
5, 6, 7, 8, 10, 14, 16 and 21	1.37	0.91, 2.05	2.10	1.32, 3.35	0.005	1.08	0.76, 1.53	1.21	0.81, 1.81	0.46
5, 6, 7, 8, 14 and 21	1.44	0.97, 2.15	2.01	1.23, 3.30	0.035	1.10	0.78, 1.55	1.15	0.76, 1.75	0.75
6, 7, 8 and 21	1.51	1.01, 2.27	1.88	1.14, 3.09	0.20	1.13	0.79, 1.59	1.07	0.69, 1.65	0.76

^aIRR, adjusted for age, sex, alcohol, infection status and smoking and for a 20 U increase in exposure.

^b95% confidence interval.

^cOUT and IN chromosome groups defined a priori based on their association with AML or MDS and benzene exposure in the literature, as described in the text.