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. 2011 Jan 6;32(4):502–506. doi: 10.1093/carcin/bgq287

Table II.

Case-only interaction between apoptotic SNPs and GERD on EA risk

SNPs GERD
ORia (95% CI) Padja
No, n (%) Yes, n (%)
PERP rs651662
    GG 68 (41.97) 43 (24.86) reference
    GA + AA 94 (58.03) 130 (75.14) 2.13 (1.33–3.40) 0.02
PERP rs648802
    CC 67 (41.36) 43 (24.86) reference
    CG + GG 95 (58.64) 130 (75.14) 2.09 (1.30–3.34) 0.02
PIK3CA rs4855094
    GG 151 (93.21) 145 (83.82) reference
    GA + AA 11 (6.79) 28 (16.18) 2.76 (1.32–5.80) 0.04
PIK3CA rs7644648
    AA 123 (75.93) 109 (63.00) reference
    GA + GG 39 (24.07) 64 (37.00) 1.89 (1.17–3.06) 0.04
TNFRSF1A rs4149579
    GG 130 (80.25) 157 (90.75) reference
    GA + AA 32 (19.76) 16 (9.25) 0.42 (0.22–0.81) 0.04
bCumulative risks of rs648802, rs4855094, rs76044648 and rs4149579
    ≤1 risk genotype 65 (40.12) 37 (21.39) reference
    2 risk genotypes 75 (46.30) 82 (47.40) 1.89 (1.13–3.16) 0.016
    ≥3 risk genotypes 22 (13.58) 54 (31.21) 4.30 (2.25–8.20) <0.0001
a

Adjusted for age, sex, BMI at age 18 (<25 versus ≥25) and smoking (+/−) (also false discovery rate for Padj).

b

Since rs651662 and rs648802 were in linkage disequilibrium, only the later was used to calculate the cumulative risks.