Table III.
Case-only interaction between apoptotic SNPs and smoking on EA risk
| SNPs | Smoking |
ORia (95% CI) | Padja | |
| No, n (%) | Yes, n (%) | |||
| TP53BP1 rs560191 | ||||
| CC | 44 (66.67) | 119 (44.24) | reference | |
| CG + GG | 22 (33.33) | 150 (45.76) | 2.58 (1.45–4.59) | 0.02 |
| TP53BP1 rs2602141 | ||||
| AA | 43 (65.15) | 118 (43.87) | reference | |
| AC + CC | 23 (34.85) | 151 (56.13) | 2.38 (1.35–4.19) | 0.02 |
| CASP7 rs7907519 | ||||
| CC | 30 (45.45) | 76 (28.25) | reference | |
| CA + AA | 36 (54.55) | 193 (71.75) | 2.14 (1.23–3.76) | 0.04 |
| BCL2 rs12454712 | ||||
| TT | 36 (54.55) | 99 (36.80) | reference | |
| TC + CC | 30 (45.45) | 170 (63.20) | 2.08 (1.20–3.63) | 0.04 |
| bCumulative risks of rs560191, rs7907519 and rs12454712 | ||||
| ≤1 risk genotype | 39 (59.09) | 85 (31.60) | reference | |
| ≥2 risk genotypes | 27 (40.91) | 184 (68.40) | 3.15 (1.80–5.52) | <0.0001 |
a
Adjusted for age, sex, BMI at age 18 (<25 versus ≥25) and GERD (+/−) (also false discovery rate for Padj).
b
Since rs560191 and rs2602141 were in linkage disequilibrium, only the former was used to calculate the cumulative risks.