Table II.
Association of the top significant SNPs of DAPK1 and TNFSF8 with risk of lung cancer in the Texas Lung cancer GWAS and replication study
| SNPs | GWAS set |
Replication set |
Pooled |
||||||
| Ca/Con | OR (95% CI) | Pa | Ca/Con | OR (95% CI) | Pa | Ca/Con | OR (95% CI) | Pa | |
| DAPK1 | |||||||||
| rs10124291 | |||||||||
| GG | 492/555 | 1.00 | 266/279 | 1.00 | 758/834 | ||||
| AG | 508/465 | 1.22 (1.02–1.45) | 0.031 | 288/282 | 1.03 (0.81–1.30) | 0.830 | 796/747 | 1.15 (1.00–1.33) | 0.051 |
| AA | 154/117 | 1.45 (1.11–1.91) | 0.007 | 68/71 | 0.96 (0.65–1.40) | 0.814 | 222/188 | 1.27 (1.02–1.58) | 0.036 |
| Additive | –– | 1.21 (1.07–1.37) | 0.003 | –– | 0.99 (0.84–1.18) | 0.942 | –– | 1.13 (1.03–1.25) | 0.013 |
| Dominant | –– | 1.26 (1.07–1.49) | 0.006 | –– | 1.01 (0.81–1.27) | 0.916 | –– | 1.17 (1.03–1.34) | 0.018 |
| Recessive | –– | 1.32 (1.02–1.71) | 0.034 | –– | 0.94 (0.66–1.35) | 0.747 | –– | 1.18 (0.96–1.46) | 0.118 |
| rs7046290 | |||||||||
| AA | 910/950 | 1.00 | 544/555 | 1.00 | 1454/1505 | 1.00 | |||
| AG | 131/97 | 1.36 (1.03–1.80) | 0.029 | 72/73 | 1.05 (0.73–1.50) | 0.780 | 203/170 | 1.23 (0.99–1.53) | 0.062 |
| GG | 8/4 | 2.25 (0.67–7.56) | 0.190 | 4/1 | 3.42 (0.38–30.9) | 0.274 | 12/5 | 2.51 (0.88–7.18) | 0.087 |
| Additive | –– | 1.42 (1.10–1.84) | 0.007 | –– | 1.12 (0.80–1.56) | 0.512 | –– | 1.30 (1.06–1.59) | 0.012 |
| Dominant | –– | 1.44 (1.09–1.89) | 0.010 | –– | 1.09 (0.77–1.54) | 0.643 | –– | 1.29 (1.04–1.59) | 0.022 |
| Recessive | –– | 2.26 (0.67–7.59) | 0.188 | –– | 3.39 (0.38–30.6) | 0.277 | –– | 2.51 (0.88–7.18) | 0.087 |
| rs3128477 | |||||||||
| GG | 488/427 | 1.00 | 244/261 | 1.00 | 732/688 | 1.00 | |||
| AG | 540/540 | 0.88 (0.74–1.06) | 0.176 | 298/279 | 1.15 (0.91–1.47) | 0.251 | 838/819 | 0.97 (0.84–1.12) | 0.659 |
| AA | 126/169 | 0.66 (0.50–0.86) | 0.002 | 80/89 | 0.97 (0.68–1.38) | 0.852 | 206/258 | 0.76 (0.61–0.94) | 0.010 |
| Additive | –– | 0.83 (0.73–0.94) | 0.003 | –– | 1.02 (0.86–1.20) | 0.834 | –– | 0.89 (0.81–0.99) | 0.023 |
| Dominant | –– | 0.83 (0.70–0.98) | 0.028 | –– | 1.09 (0.87–1.38) | 0.441 | –– | 0.91 (0.80–1.05) | 0.184 |
| Recessive | –– | 0.70 (0.55–0.90) | 0.005 | –– | 0.89 (0.64–1.24) | 0.493 | –– | 0.77 (0.63–0.94) | 0.009 |
| TNFSF8 | |||||||||
| rs2181033 | |||||||||
| AA | 491/431 | 1.00 | 213/203 | 1.00 | 704/634 | 1.00 | |||
| AG | 520/514 | 0.89 (0.75–1.07) | 0.216 | 304/332 | 0.86 (0.67–1.10) | 0.237 | 824/846 | 0.88 (0.76–1.01) | 0.072 |
| GG | 143/192 | 0.65 (0.51–0.84) | 0.001 | 96/93 | 0.98 (0.69–1.38) | 0.904 | 239/285 | 0.76 (0.62–0.93) | 0.008 |
| Additive | –– | 0.83 (0.73–0.93) | 0.002 | –– | 0.98 (0.83–1.15) | 0.763 | –– | 0.88 (0.79–0.96) | 0.007 |
| Dominant | –– | 0.83 (0.70–0.98) | 0.027 | –– | 0.91 (0.71–1.15) | 0.424 | –– | 0.85 (0.74–0.98) | 0.022 |
| Recessive | –– | 0.69 (0.55–0.88) | 0.002 | –– | 1.08 (0.79–1.45) | 0.628 | –– | 0.82 (0.68–0.99) | 0.036 |
CI, confidence interval; OR, odds ratio.
a
Adjusted for age, sex, smoking status and pack-years.