Table III.
Putative functional SNPs in the TNFSF8 region that are in high LD with rs2181033, based on the genotype information in the CEU population in the HapMap
| SNP | Gene region | LD SNP | r2 | Allele change | Allele | Allele frequency | Putative function changea |
| rs927375 | 5′ flanking | rs2181033 | 0.764 | A/G | A | 0.417 | NA |
| rs2181033 | 5′ flanking | rs2181033 | 1.000 | A/G | A | 0.656 | NA |
| rs1322060 | 5′ flanking | rs2181033 | 0.857 | C/G | C | 0.621 | NA |
| rs1322059 | 5′ flanking | rs2181033 | 0.924 | G/T | C | 0.633 | NA |
| rs726656 | 5′ flanking, −3678 bp | rs2181033 | 0.924 | A/C | A | 0.633 | TFBS |
| rs726657 | 5′ flanking, −3566 bp | rs2181033 | 0.809 | A/G | C | 0.607 | TFBS |
| rs3181348 | 5′ flanking, −1414 bp | rs2181033 | 0.794 | A/C | A | 0.401 | TFBS |
| rs2075533 | 5′ flanking, −861 bp | rs2181033 | 0.795 | T/C | A | 0.397 | TFBS |
| rs1006027 | Intron | rs2181033 | 0.814 | G/A | T | 0.617 | NA |
| rs1006026 | Intron | rs2181033 | 0.763 | G/A | G | 0.405 | NA |
| rs1006025 | Intron | rs2181033 | 0.814 | T/C | C | 0.617 | NA |
| rs7036962 | Intron | rs2181033 | 0.814 | G/A | G | 0.617 | NA |
| rs10982455 | Intron | rs2181033 | 0.869 | G/A | C | 0.634 | NA |
| rs4979472 | Intron | rs2181033 | 0.751 | G/A | G | 0.411 | NA |
| rs1322058 | Intron | rs2181033 | 0.869 | G/A | C | 0.634 | NA |
| rs10982451 | Intron | rs2181033 | 0.814 | T/C | C | 0.617 | NA |
| rs7872878 | Intron | rs2181033 | 0.772 | G/C | C | 0.434 | NA |
| rs10982450 | Intron | rs2181033 | 0.812 | T/G | G | 0.617 | NA |
| rs3789879 | Intron | rs2181033 | 0.751 | T/C | C | 0.411 | NA |
| rs4978611 | Intron | rs2181033 | 0.751 | C/T | C | 0.411 | NA |
| rs927373 | Intron | rs2181033 | 0.869 | A/G | G | 0.634 | NA |
| rs2208640 | Intron | rs2181033 | 0.814 | A/G | A | 0.617 | NA |
| rs12337739 | Intron | rs2181033 | 0.751 | C/G | T | 0.411 | NA |
| rs17292087 | Intron | rs2181033 | 0.829 | A/G | C | 0.643 | NA |
| rs3181195 | Intron | rs2181033 | 0.849 | A/G | C | 0.638 | NA |
| rs3181363 | Intron | rs2181033 | 0.774 | C/T | C | 0.625 | NA |
| rs3181364 | Intron | rs2181033 | 0.769 | A/T | A | 0.627 | NA |
| rs3181366 | Intron | rs2181033 | 0.774 | G/A | G | 0.625 | NA |
| rs3181367 | Intron | rs2181033 | 0.730 | A/C | A | 0.406 | NA |
| rs3181369 | 3′ UTR | rs2181033 | 0.832 | C/T | G | 0.634 | microRNA-binding site |
| rs3181370 | 3′ UTR | rs2181033 | 0.839 | G/T | T | 0.638 | microRNA-binding site |
| rs3181372 | 3′ UTR | rs2181033 | 0.730 | C/T | G | 0.406 | microRNA-binding site |
| rs1126711 | 3′ UTR | rs2181033 | 0.742 | C/T | G | 0.401 | microRNA-binding site |
| rs3181374 | 3′ UTR | rs2181033 | 0.744 | A/G | G | 0.402 | microRNA-binding site |
| rs2295800 | 3′ flanking | rs2181033 | 0.723 | C/T | C | 0.397 | NA |
| rs3181200 | 3′ flanking | rs2181033 | 0.744 | T/C | T | 0.402 | NA |
| rs3181201 | 3′ flanking | rs2181033 | 0.744 | G/A | C | 0.402 | NA |
| rs7025577 | 3′ flanking | rs2181033 | 0.725 | G/A | A | 0.405 | NA |
| rs1322067 | 3′ flanking | rs2181033 | 0.730 | G/A | A | 0.594 | NA |
| rs10982445 | 3′ flanking | rs2181033 | 0.709 | C/G | C | 0.402 | NA |
| rs1407309 | 3′ flanking | rs2181033 | 0.723 | A/C | A | 0.397 | NA |
a
NA, not applicable; TFBS, transcription factor-binding site; UTR, untranslated region.