Table 4.
Anxiety and depression scores as assessed by HADS in patients with congenital adrenal hyperplasia (n = 129), compared with normative data
| Male classic CAH (n = 33/62, 51%) | Age- and sex- matched controls (n = 165) | Female classic CAH (n = 65/103, 63%) | Age- and sex- matched controls (n = 325) | Female nonclassic CAH (n = 31/31, 100%) | Age- and sex- matched controls (n = 155) | |
|---|---|---|---|---|---|---|
| HADS anxiety score | ||||||
| Median (IQR) | 6.5 (3.3–8.0) | 3.0 (2.0–4.3) | 9.0 (6.0–12.5) | 4.0 (2.0–6.0) | 8.0 (5.0–11.0) | 4.0 (2.0–7.0) |
| Pa | <0.001 | <0.001 | <0.001 | |||
| HADS depression score | ||||||
| Median (IQR) | 2.0 (1.0–5.5) | 2.0 (0.8–4.0) | 5.0 (1.0–7.0) | 2.0 (1.0–5.0) | 4.0 (1.5–9.0) | 3.0 (1.0–6.0) |
| Pa | 0.397 | <0.001 | 0.086 |
For every patient, five sex- and age-matched controls were selected from the normative group (n = 2043). Data are given as mean ± sem, median, and interquartile range (IQR, 25th–75th percentile). The higher the score, the worse is the perceived impairment of mood.
a
P for comparison CAH subgroup vs. sex- and age-matched controls.