Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
HMGB1 induces MMP-9 expression in neurons and astrocytes. Primary cultured neurons and astrocytes were treated with different doses of HMGB1 (A; 6h incubation) for various incubation periods (B; 100ng/ml of HMGB1). MMP-9 expression in the cells increases in a time and dose-dependent manner. C: Gel zymography confirms MMP-9 upregulation in the conditioned media from astrocytes. No MMP-2 is detected in the media. The data are the means±SD. *: p<0.05.
