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HMGB1-induced MMP-9 upregulation is attenuated in TLR4 mutant neurons and astrocytes. Neurons and astrocytes were isolated from either C3H/Heouj (wild-type) or C3H/Hej (mutant) mice and treated with 100ng/ml HMGB1 for 6 hours. MMP-9 expression was analyzed by real time PCR. The data show means±SD relative to control. *: <0.01.
