Table 2.

Application of liposomes for the delivery of various drug molecules.

Drug	Formulation	Result	Year	Ref
GCV	Liposomes	In vitro transcorneal permeation and in vivo ocular pharmacokinetics was improved	2007	[26]
Ciprofloxacin	Liposomal hydrogel	Fivefold higher transcorneal permeation than the liposomes alone	2010	[27]
Levofloxacin	Liposomes attached to the contact lens	Drug was released following first-order kinetics for more than 6 days and formulation had showed activity against S. aureus.	2007	[28]
Herpes simplex virus antigens	Periocular vaccine	Treated rabbits showed anti-gB immune response and protected against reactivation of HSV infection	2006	[29]
Acetazolamide	Neutral- and surface-charged liposomes	Positively charged liposomes reduced IOP and exhibited prolonged effect than negatively charged liposomes	2007	[30]
Tacrolimus	Liposomes	More than 50 ng/mL vitreous concentration was maintained for 2 weeks and reduced drug related toxicity	2010	[31]
Vasoactive intestinal peptide	Rhodamine-conjugated liposomes	Liposomes were internalized by retinal Müller glial cells, resident macrophages; majority of the liposomes reached the cervical lymph nodes and resulted in slower release and long-term expression inside the eye	2007	[32]
Clodronate	Liposomes	Effectively inhibit infiltration of ED2-positive macrophages	2005	[33]
Plasmid DNA	Cationic liposomes	Significantly increased transfection efficiency of pDNA	2004	[34]
Therapeutic DNA	Cationic lipoplexes	Achieved good vitreous mobility with moderately pegylated cationic lipoplexes with size less than 500 nm	2005	[35]