Figure 4.

The signaling pathways that sense and respond to EGCG through 67LR are depicted. After EGCG binding to lipid raft-associated 67LR, through eEF1A, the phosphorylation of MYPT1 at Thr-696 but not Thr-853 is reduced, which leads to the activation of myosin phosphatase. The activated myosin phosphatase dephosphorylates its substrates (e.g. MRLC), and actin cytoskeleton rearrangement is induced. The alteration of actin cytoskeleton might lead to cell growth inhibition. EGCG also induces apoptosis in the 67LR-expressing cells derived from multiple myeloma and acute myeloid leukaemia patient samples.