. Author manuscript; available in PMC: 2012 Mar 24.

Published in final edited form as: J Med Chem. 2011 Feb 24;54(6):1555–1564. doi: 10.1021/jm101323b

Table 1.

D₂, D₃ and D₄ Affinities (K_i ± SD, nM) of the benzamide analogs.

	D₂	D₃	D₄	D₂/D₃ Ratio	Log P^a
1	34.4 ± 4.7	0.8 ± 0.1	896 ± 272	43	3.09
2	54.5 ± 4.4	2.4 ± 0.4	804 ± 46	23	2.94
18a	27.1 ± 3.5	1.1 ± 0.1	1,400 ± 320	25	3.48
18b	20.9 ± 3.7	6.2 ± 0.9	ND	3.4	3.08
18c	52.0 ± 6.6	4.2 ± 0.2	2,100 ± 380	12.2	2.72
19a	131 ± 13	24.9 ± 3.3	ND	5.2	3.43
19b	55.3 ± 6.0	6.2 ± 0.3	ND	8.9	3.55
19c	59.2 ± 5.8	18.2 ± 2.3	ND	3.3	3.16
19d	17.8 ± 0.8	18.5 ± 2.4	ND	1	3.66
19e	13.4 ± 2.3	13.6 ± 2.0	ND	1	4.49
19f	13.2 ± 0.8	10.9 ± 1.5	ND	1.2	4.73
19g	57.6 ± 3.7	13.8 ± 1.2	ND	4.2	4.15
20a	15.1 ± 1.7	0.65 ± 0.2	890 ± 100	23	3.75
20b	21.4 ± 2.9	6.9 ± 1.0	ND	3.1	3.68
20c	15.1 ± 2.7	0.52 ± 0.03	990 ± 200	29	3.73
20d	14.2 ± 1.9	2.5 ± 0.3	ND	5.7	3.34
20e	27.7 ± 5.4	0.17 ± 0.01	246 ± 13	163	4.67
20f	31.7 ± 2.1	5.2 ± 0.3	ND	6.1	2.98
21a	35.2 ± 2.5	3.6 ± 0.6	ND	9.8	3.83
21b	17.7 ± 2.7	1.1 ± 0.2	890 ± 380	16.1	3.61
21c	37.9 ± 5.0	8.4 ± 1.3	ND	4.5	3.81
21d	64.8 ± 8.4	19.6 ± 3.2	ND	3.3	3.41
21e	70.5 ± 9.6	1.1 ± 0.2	182 ± 5	64	4.74
21f	25.9 ± 2.4	11.2 ± 2.2	ND	2.3	3.26
21g	10.9 ± 0.4	6.7 ± 1.1	ND	1.6	3.72
21h	12.0 ± 0.6	3.1 ± 0.3	ND	3.9	4.36

Calculated using ACD log D software, Advanced Chemistry Development, Toronto, Canada.