. Author manuscript; available in PMC: 2012 Mar 24.

Published in final edited form as: J Med Chem. 2011 Feb 24;54(6):1555–1564. doi: 10.1021/jm101323b

Table 2. Sigma Receptor Affinities (K_i ± SD [nM]) of Selected Analogs.

	D₃	σ₁	σ₂	D₃/ σ₁ Ratio	D₃/ σ₂ ratio
1	0.8 ± 0.1	1,260 ± 290	1,570 ± 310	1,573	1,970
2	2.4 ± 0.4	3,540 ± 2500	2,210 ± 260	1,476	919
18a	1.1 ± 0.1	4,780 ± 730	660 ± 36	4344	601
18c	4.2 ± 0.2	4,870 ± 470	1,120 ± 30	1,159	266
20a	0.65 ± 0.2	1,960 ± 50	650 ± 38	3,017	1,002
20c	0.52 ± 0.03	4,360 ± 570	794 ± 14	8,377	1,527
20e	0.17 ± 0.01	20,900 ± 5250	5,960 ± 360	122,706	35,047
21b	1.1 ± 0.2	7,200 ± 880	2,020 ± 260	6,541	1,839
21e	1.1 ± 0.2	7,780 ± 540	1,320 ± 33	7,076	1,200
Haloperidol	–	1.5 ± 0.3	24.2 ± 3.0	–	–

Table 2. Sigma Receptor Affinities (Ki ± SD [nM]) of Selected Analogs.