. Author manuscript; available in PMC: 2011 Mar 30.

Published in final edited form as: Toxicol Appl Pharmacol. 2008 Oct 7;234(2):156–165. doi: 10.1016/j.taap.2008.09.020

Table 2. The top biological functions generated by IPA for the significant genes list of 24 h, 72 h, and 168.

Biological function	−log (p-value)/genes

	24 h	72 h	168 h
Cell death	17.5 (511)	17.3 (528)	17.3 (580)
Cancer	12.6 (566)	17.2 (623)	14.2 (687)
Inflammatory disease	11.5 (226)	17.8 (271)	18.4 (295)
Immunological disease	10.3 (228)	17.1 (260)	18.5 (287)
Cell movement	9.5 (311)	12.5 (323)	22.6 (401)

P-value represents the statistical significance of the specific biological function, and −log(p-value) increases with the statistical significance (−log(p-value)=1.30 when p-value=0.05). The number under the dash represents that the number of genes in a gene list was involved in a biological function. Results in this table shows that inflammation plays an important role in the etiology of SM-induced cutaneous injury. The total number of genes affected are in parentheses.