Table 5. Genes involved in NF-kB signaling pathway induced by sulfur mustard at 24, 72 and 168 h post-exposure.
Gene name | Gene description | Fold change (SM) | ||
---|---|---|---|---|
24 h | 72 h | 168 h | ||
Akt2 | v-akt murine thymoma viral oncogene homolog 2 | 1.78† | 1.46* | 1.41† |
Ep300 | E1A binding protein p300 | −1.72* | −2.13* | −2.13* |
Ghr | Growth hormone receptor | −1.66* | −1.52* | −1.18 |
Ikbkg | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 1.59* | 1.80† | 1.48* |
Il1b | Interleukin 1, beta | 35.29† | 34.18† | 51.94† |
Il1rn | Interleukin 1 receptor antagonist | 1.84† | 1.18 | 1.72† |
Irak3 | Interleukin-1 receptor-associated kinase 3 | 2.78* | 1.98 | 1.77* |
Map3k7 | Mitogen-activated protein kinase 8 | 1.66† | 1.3† | 1.74* |
Nfkbia | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1.66* | 1.43 | 1.62* |
Nfkbie | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 1.66 | 1.99 | 3.97* |
Ngfb | Nerve growth factor, beta polypeptide | 13.52† | 11.37† | 6.15* |
Pik3c2g | Phosphoinositide-3-kinase, class 2, gamma polypeptide | −2.56† | −2.13* | −2.44† |
Pik3cd | Phosphoinositide-3-kinase, catalytic, delta polypeptide | 1.13 | 1.79 | 2.35* |
Pik3cg | Phosphoinositide-3-kinase, catalytic, gamma polypeptide | 1.29* | 2.35* | 3.12† |
Pik3r1 | Phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1.03 | −1.28* | −1.39* |
Pik3r5 | Phosphoinositide-3-kinase, regulatory subunit 5, p101 | 2.01* | 3.36* | 4.14† |
Rras2 | Related RAS viral (r-ras) oncogene homolog 2 | 1.94* | 1.98* | 1.79† |
Tgfa | Transforming growth factor, alpha | 1.57 | 2.36† | 2.24* |
Tirap | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 1.73* | 1.60* | 1.54* |
Tlr1 | Toll-like receptor 1 | 3.13† | 6.83† | 5.76† |
Tlr2 | Toll-like receptor 2 | 2.25 | 3.34* | 3.75* |
Tlr3 | Toll-like receptor 3 | 1.05 | 1.56† | 2.22† |
Tlr4 | Toll-like receptor 4 | 1.64 | 1.85† | 1.93* |
Tnfaip3 | Tumor necrosis factor, alpha-induced protein 3 | 3.12† | 1.23 | 2.95† |
Traf3 | TNF receptor-associated factor 3 | 1.65* | 1.72 | 2.18* |
p<0.05.
p<0.01.