Table 7. Genes involved in p38 MAPK pathway induced by sulfur mustard at 24, 72 and 168 h post-exposure.
Gene name | Gene description | Fold change (SM) | ||
---|---|---|---|---|
24 h | 72 h | 168 h | ||
Creb1 | cAMP responsive element binding protein 1 | 2.92* | 9.38* | 7.89* |
Ddit3 | DNA-damage-inducible transcript 3 | 1.62* | 1.23 | 1.14 |
Eef2k | Eukaryotic elongation factor-2 kinase | −1.58† | −1.80* | −1.60† |
Fas | Fas (TNF receptor superfamily, member 6) | 2.88† | 2.10* | 1.89† |
H3f3a | H3 histone, family 3A | 1.81* | 1.05 | 1.17 |
H3f3b | H3 histone, family 3B (H3.3B) | 2.10* | −1.13 | −1.18 |
Il18 | Interleukin 18 (interferon-gamma-inducing factor) | −2.56* | −1.08 | −1.15 |
Il1b | Interleukin 1, beta | 35.29† | 34.18† | 51.94† |
Il1rn | Interleukin 1 receptor antagonist | 1.84† | 1.18 | 1.72 |
Irak3 | Interleukin-1 receptor-associated kinase 3 | 2.78* | 1.98 | 1.77 |
Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | 1.66† | 1.38* | 1.74* |
Mapk13 | Mitogen-activated protein kinase 13 | −1.56* | 1.16 | −1.30 |
Mef2a | Myocyte enhancer factor 2A | −1.00 | 1.41* | 1.74* |
Pla2g4b | Phospholipase A2, group IVB (cytosolic) | 1.48* | 1.69* | 1.40 |
Rps6ka4 | Ribosomal protein S6 kinase, 90 kDa, polypeptide 4 | 1.87† | 1.92† | 1.60† |
Rps6ka5 | Ribosomal protein S6 kinase, polypeptide 5 | −1.61† | −1.13 | 1.41 |
Stat1 | Signal transducer and activator of transcription 1 | 1.49* | 1.56* | 1.73† |
Tgfb2 | Transforming growth factor, beta 2 | −1.70* | −1.89* | −1.68* |
Tgfb3 | Transforming growth factor, beta 3 | −4.17† | −1.67 | −1.54 |
Tradd | TNFRSF1A-associated via death domain | 1.54† | 1.33 | 1.22 |
p<0.05.
p<0.01.