Table 9. Genes involved in the apoptosis signaling pathway induced by sulfur mustard at 24, 72 and 168 h post-exposure.
Gene name | Gene description | Fold change (SM) | ||
---|---|---|---|---|
24 h | 72 h | 168 h | ||
Akt2 | v-akt murine thymoma viral oncogene homolog 2 | 1.78† | 1.46* | 1.41† |
Bax | BCL2-associated X protein | 3.38† | 2.56† | 2.23† |
Bid | BH3 interacting domain death agonist | 1.97† | 2.54* | 2.08* |
Capn3 | Calpain 3, (p94) | 1.47 | 1.61 | 2.16† |
Capn5 | Calpain 5 | −2.20 | −1.49 | −2.44* |
Casp8 | Caspase 8, apoptosis-related cysteine peptidase | 1.31 | 1.53* | 1.72† |
Fas | Fas (TNF receptor superfamily, member 6) | 2.88† | 2.10* | 1.89† |
Ikbkg | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1.59* | 1.80† | 1.48* |
Map2k1 | Mitogen-activated protein kinase kinase 1 | 1.69* | 2.27* | 2.02† |
Nfkbia | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 1.66* | 1.43 | 1.62* |
Nfkbie | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 1.66 | 1.99 | 3.97* |
Pak3 | p21 (CDKN1A)-activated kinase 3 | −1.69 | −1.70† | −2.19† |
Pkn1 | Protein kinase N1 | 1.61 | 1.35 | 2.48* |
Rras2 | Related RAS viral (r-ras) oncogene homolog 2 | 1.94* | 1.98* | 1.79† |
Ttk | TTK protein kinase | −1.24 | 1.04 | −2.13* |
p<0.05.
p<0.01.