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. 2010 Dec 6;55(3):1237–1247. doi: 10.1128/AAC.00595-10

FIG. 4.

FIG. 4.

Single-dose pharmacokinetic plasma drug levels of standard TB drugs in BALB/c mice when the drugs were administered as drug combinations. (A) INH drug levels over time when administered with PZA 4 h after RIF in DMSO (⧫) or water (□). (B) INH concentrations when administered with PZA 4 h before RIF was given in DMSO (⧫) or water (□). The data in the graphs are shown from the time of RIF administration. (C) INH concentrations when INH was given alone (⧫) or in combination with PZA (□) without RIF. (D) RIF concentrations after PZA and INH, RIF in DMSO (⧫), or water (□). (E) RIF concentrations when RIF in DMSO (⧫) or water (□) was given 4 h before PZA and INH. (F) RIF plasma levels when given alone in water (□) or DMSO (⧫). (G) PZA concentrations when RIF was administered 4 h before PZA and INH, with RIF dissolved in DMSO (⧫) or water (□). (H) PZA concentrations when PZA and INH were given 4 h prior to RIF dissolved in DMSO (⧫) or water (□). (I) PZA plasma concentrations when PZA was given alone (⧫) or in combination with INH (□). Doses: INH, 25 mg/kg; RIF, 10 mg/kg; PZA, 150 mg/kg (as a single dose by oral gavage). All time points refer to the time after RIF administration.