TABLE 3.
Clearance of doripenem and doripenem-M-1 by CVVH and CVVHDFa
| Drug/product and parameter | Result for CVVH subjects (n = 6) | Result for CVVHDF subjects (n = 5) | P value |
|---|---|---|---|
| Doripenem | |||
| QCRRT (liter/h) | 1.99 (0.0272) | 1.96 (0.0487) | 0.2967 |
| Sc or Sa | 0.67 (0.15) | 0.76 (0.16) | 0.4119 |
| AUC0-12 (μg·h/ml) | 63.5 (30.7) | 53.6 (11.4) | 0.5143 |
| AeCRRT (% per dose) | 27.5 (12.5) | 20.5 (3.99)b | 0.3213 |
| CLCRRT (ml/min) | 22.2 (4.99) | 24.5 (5.03) | 0.6254 |
| %CLCRRT | 32.0 (15.2) | 25.4 (5.06) | 0.2795 |
| Doripenem-M-1 | |||
| Sc or Sa | 0.82 (0.11) | 0.93 (0.17) | 0.4119 |
| AUC0-12 (μg·h/ml) | 18.7 (4.10) | 18.9 (4.90) | 0.2094 |
| AeCRRT (% per dose) | 10.1 (3.82) | 8.44 (1.65)b | 0.9571 |
| CLCRRT (ml/min) | 27.1 (3.59) | 30.3 (5.00) | 0.2515 |
| Urea | |||
| CLurea (ml/min) | 26.8 (6.22) | 26.7 (8.33) | NAc |
a
Data are presented as means (SD) unless otherwise noted.
b
n = 4.
c
NA, not assessable.