FIG. 4.

Dextromethorphan reduces viable bacterial numbers in infiltrating cells in the air pouch of GAS-infected mice. Mice were inoculated with 3 × 10⁸ CFU of NZ131 with or without the administration of DM 30 min before and 1, 12, and 24 h after NZ131 infection (n = 5 per group of GAS with saline and n = 7 per group of GAS with DM). The air pouch exudates were collected 36 h after NZ131 infection. The infiltrating cell numbers (A), cell viability (B), and bacterial numbers in infiltrating cells (C) were determined (*, P < 0.05). The experiments were performed three times, and one set of representative data is shown.