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Dextromethorphan reduces inflammatory cytokine and chemokine levels in sera of GAS-infected mice. Mice were inoculated with 3 × 108 CFU of NZ131 with or without the administration of DM 30 min before and 1, 12, and 24 h after NZ131 infection (n = 6 per group of GAS with saline and n = 7 per group of GAS with DM). The sera were collected 48 h after NZ131 infection, and the amounts of inflammatory cytokines (A) and chemokines (B) were determined by ELISA (*, P < 0.05; **, P < 0.01).
