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Dextromethorphan reduces AST levels in sera of GAS-infected mice. Mice were inoculated with 3 × 108 CFU of NZ131 with or without the administration of DM 30 min before and 1, 12, and 24 h after NZ131 infection. The sera were collected 48 h after NZ131 infection for AST measurements (n = 5 for the untreated group, n = 6 for the GAS-alone group, and n = 6 for GAS and DM group) (*, P < 0.05; **, P < 0.01).
