TABLE 1.
Darunavir, ritonavir, and etravirine exposures in blood plasma and cervicovaginal fluid
| PK parametera | Median value (IQR) |
|||||
|---|---|---|---|---|---|---|
| Darunavir (n = 8) |
Ritonavir (n = 8) |
Etravirineb (n = 2) |
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| BP | CVF | BP | CVF | BP | CVF | |
| Cmax (ng/ml) | 7,045 (4,954-8,015) | 12,020 (7,951-14,032) | 696 (547-1,134) | 735 (612-1,603) | 873 | 4,558 |
| Tmax (h) | 2.5 (2-3) | 5 (3-7) | 4 (4-6) | 7 (3-10) | 4 | 5 |
| AUC12h (ng·h/ml) | 63,371 (40,604-67,641) | 73,037 (52,414-101,752) | 4,572 (3,505-7,385) | 5,601 (3,306-6,959) | 8,870 | 11,963 |
| CVF/BP AUC12h ratioc | 1.5 (1.0-1.6) | 0.8 (0.6-1.6) | 1.3 | |||
a
Cmax, maximum plasma concentration; Tmax, time to reach Cmax; AUC12h, area under the concentration-time curve at 12 h.
b
Data are medians only.
c
Data represent the medians(IQR) of the individual ratios rather than the median concentrations.