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. 2010 Dec 28;55(3):1088–1096. doi: 10.1128/AAC.01181-10

TABLE 2.

Inhibition of bacterial DNA ligase enzymes by the adenosine analogsa

Compound IC50 (μM) for DNA ligase from:
H. influenzae E. coli S. pneumoniae S. aureus M. pneumoniae
1 0.507 1.27 0.136 0.081 0.075
2 0.076 0.158 0.052 0.063 0.021
3 0.112 0.370 0.076 0.117 0.019
4 0.106 0.320 0.039 0.158 <0.010
5 0.082 0.180 0.038 0.060 0.062
a

The chemical structures of the adenosine analogs are shown in Fig. 1.