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DNA ligase mode-of-action confirmation using recombinant expression strains
| Compounda | MICb |
|||||
|---|---|---|---|---|---|---|
|
H. influenzae |
S. pneumoniae |
|||||
| HIN101 | HIN102 | Fold increase | SPN100 | SPN102 | Fold increase | |
| LVX | 0.01 | 0.01 | 0.5 | 0.5 | ||
| LZD | 4 | 4 | 0.5 | 0.5 | ||
| 1 | 32 | 512 | 16 | ND | ND | |
| 2 | 4 | >64 | >16 | 2 | >64 | >32 |
| 3 | 8 | >64 | >8 | 2 | >64 | >32 |
| 4 | 2 | 32 | 16 | 1 | >64 | >64 |
LVX, levofloxacin; LZD, linezolid.
MICs for strains are given in micrograms per milliliter. ND, not determined.
