TABLE 3.
Adjusted association between agr dysfunction and mortality, stratified by severity of illness
| Quartile based on severity of illness | Mortality (%) among patients infected with S. aureus |
Association between agr dysfunction and mortality (adjusted HR [95% CI])a | |
|---|---|---|---|
| Strains with dysfunctional agr | Strains with functional agr | ||
| 4th (modified APS of >28; n = 216 [27% of patients]) | 44.0 | 25.3 | 1.82 (1.03-3.21) |
| 3rd (modified APS of >17 and ≤28; n = 195 [24% of patients]) | 14.8 | 13.5 | 1.01 (0.41-2.48) |
| 2nd (modified APS of >9 and ≤17; n = 208 [26% of patients]) | 4.2 | 5.0 | 0.43 (0.08-2.47) |
| 1st (modified APS of ≤9; n = 195 [24% of patients]) | 3.3 | 4.2 | 0.28 (0.02-3.40) |
a
Statistically adjusted for vancomycin MIC, receipt of vancomycin, aggregate comorbidity, methicillin resistance, presence of a central venous catheter, previous admission in the past year, and age, using Cox proportional hazard models.