TABLE 3.
Ex vivo drug susceptibility for paired isolates tested at the ring (>90% before culture) and trophozoite (>90% after culture) stage
| Antimalarial |
P. falciparumassay |
P. vivaxassay |
||||||
|---|---|---|---|---|---|---|---|---|
| na | Median IC50(range) (nM) for: |
Pb | n | Median IC50(range) (nM) for: |
P | |||
| Rings | Trophozoites | Rings | Trophozoites | |||||
| Chloroquine | 8 | 30.2 (14.0-97.1) | 63.2 (21.0-673.3) | 0.036 | 9 | 53.0 (8.8-81.4) | 841.4 (133-1930) | 0.008 |
| Amodiaquine | 8 | 5.7 (1.0-28.6) | 9.6 (4.5-40.5) | 0.025 | 8 | 10.1 (3.9-15.5) | 21.1 (4.0-36.3) | 0.036 |
| Piperaquine | 8 | 11.5 (4.4-46.9) | 87.6 (30.4-692.7) | 0.012 | 9 | 15.5 (3.7-34.8) | 15.9 (1.32-42.5) | 0.515 |
| Mefloquine | 6 | 6.4 (2.7-12.7) | 19.9 (6.4-22.5) | 0.046 | 7 | 9.2 (1.5-23.2) | 10.2 (2.3-27.2) | 0.612 |
| Artesunate | 8 | 0.88 (0.31-4.11) | 1.19 (0.59-4.18) | 0.400 | 8 | 0.75 (0.09-1.03) | 0.39 (0.2-1.09) | 0.484 |
| SAHA | 8 | 329 (232-482) | 520 (346-1016) | 0.036 | 9 | 159 (67-223) | 147 (40-229) | 0.767 |
| 2-ASA-9 | 4 | 492 (463-533) | 519 (362-988) | 1.000 | 9 | 545 (203-710) | 438 (149-2491) | 0.767 |
| 2-ASA-14 | 6 | 238 (209-704) | 467 (273-1043) | 0.028 | 9 | 327 (121-502) | 214 (145-588) | 0.110 |
a
n is the number of paired isolates.
b
The Pvalues compare the median IC50 values for rings and trophozoites by the Wilcoxon rank sum test. The statistically significant values are shown in boldface type.