TABLE 2.
RAL resistant mutations detected at baseline and after treatment failure
| Mutation | No. of patients with the mutation |
|
|---|---|---|
| Baselinea | Treatment failureb | |
| Q148R | 2 | 0 |
| Q148K | 1 | 0 |
| Q148H | 1 | 0 |
| G140S | 9 | 3 |
| G140A | 0 | 0 |
| N155H | 1 | 1 |
| L74M | 3 | 1 |
| E92Q | 1 | 0 |
| T97A | 5 | 1 |
| Y143R | 2 | 0 |
| Y143C | 3 | 0 |
| Y143H | 4 | 0 |
Determined by PASS.
Determined by populaiotn sequencing.