TABLE 2.
Correlations between genotypic and phenotypic resistance to levofloxacin at different MIC breakpoints
| MIC (μg/ml) | GyrA mutation |
P | Kappa coefficient | Accuracya |
||
|---|---|---|---|---|---|---|
| No | Yes | Sensitivity | Specificity | |||
| ≤8 | 280 | 18 | <0.001 | 0.277 | 80 (4/5) | 94 (280/298) |
| >8 | 1 | 4 | 18.2 (4/22) | 99.6 (280/281) | ||
| ≤4 | 279 | 13 | <0.001 | 0.522 | 81.8 (9/11) | 95.5 (279/292) |
| >4 | 2 | 9 | 40.9 (9/22) | 99.3 (279/281) | ||
| ≤1 | 279 | 7 | <0.001 | 0.754 | 88.2 (15/17) | 97.6 (279/286) |
| >1 | 2 | 15 | 68.2 (15/22) | 99.3 (279/281) | ||
| ≤0.5 | 244 | 7 | <0.001 | 0.338 | 28.8 (15/52) | 97.2 (244/251) |
| >0.5 | 37 | 15 | 68.2 (15/22) | 86.8 (244/281) | ||
a
Sensitivity is given as a percentage (number found positive/total number positive by the gold standard). Specificity is given as a percentage (number found negative/total number negative by the gold standard). The MIC test was used as the gold standard for the calculation of accuracy.