TABLE 3.
Correlations between genotypic and phenotypic resistance to clarithromycin at different MIC breakpoints
| MIC (μg/ml) | 23S rRNA mutation |
P | Kappa coefficient | Accuracya |
||
|---|---|---|---|---|---|---|
| No | Yes | Sensitivity | Specificity | |||
| ≤16 | 283 | 12 | <0.001 | 0.589 | 84.6 (11/13) | 95.9 (283/295) |
| >16 | 2 | 11 | 47.8 (11/23) | 99.3 (283/285) | ||
| ≤8 | 281 | 9 | <0.001 | 0.661 | 77.8 (14/18) | 96.9 (281/290) |
| >8 | 4 | 14 | 60.9 (14/23) | 98.6 (281/285) | ||
| ≤2 | 281 | 8 | <0.001 | 0.694 | 78.9 (15/19) | 97.2 (281/289) |
| >2 | 4 | 15 | 65.2 (15/23) | 98.6 (281/285) | ||
| ≤1 | 276 | 8 | <0.001 | 0.608 | 62.5 (15/24) | 97.2 (276/284) |
| >1 | 9 | 15 | 65.2 (15/23) | 96.8 (276/285) | ||
| ≤0.5 | 271 | 8 | <0.001 | 0.538 | 51.7 (15/29) | 97.1 (271/279) |
| >0.5 | 14 | 15 | 65.2 (15/23) | 95.1 (271/285) | ||
a
Sensitivity is given as a percentage (number found positive/total number positive by the gold standard). Specificity is given as a percentage (number found negative/total number negative by the gold standard). The MIC test was used as the gold standard for the calculation of accuracy.