TABLE 5.
Correlations between genotypic and phenotypic resistance to clarithromycin and eradication rates (per- protocol analysis) after first-line clarithromycin-based triple therapy
| 23S genotype or MIC | No. of patients for whom H. pylori was: |
Eradication rate (%) | P | Kappa coefficient | |
|---|---|---|---|---|---|
| Eradicated | Not eradicated | ||||
| 23S rRNA | |||||
| No mutation | 130 | 9 | 93.5 | <0.001 | 0.687 |
| Mutation | 1 | 12 | 7.7 | ||
| MIC (μg/ml) | |||||
| ≤16 | 131 | 16 | 89.1 | 0.014 | 0.180 |
| >16 | 0 | 2 | 0 | ||
| ≤8 | 129 | 13 | 90.8 | <0.001 | 0.356 |
| >8 | 2 | 5 | 28.6 | ||
| ≤2 | 129 | 13 | 90.8 | <0.001 | 0.356 |
| >2 | 2 | 5 | 28.6 | ||
| ≤1 | 126 | 13 | 89.4 | 0.003 | 0.296 |
| >1 | 5 | 5 | 50 | ||
| ≤0.5 | 123 | 13 | 90.4 | 0.010 | 0.246 |
| >0.5 | 8 | 5 | 61.5 | ||