TABLE 2.
MICs of macrolides and related compounds against S. agalactiae UCN70 clinical isolate, S. agalactiae BM132 reference strain, and BM132 transformants harboring pAT28 plasmid or lsa(C)-containing pAT28 plasmid
| Antibiotic | MIC (μg/ml) for S. agalactiae strain or isolate |
|||
|---|---|---|---|---|
| UCN70 | BM132 | BM132/ pAT28 | BM132/ pAT28Ωlsa(C) | |
| Macrolides | ||||
| Erythromycin | 0.06 | 0.06 | 0.06 | 0.06 |
| Azithromycin | 0.03 | 0.03 | 0.03 | 0.03 |
| Spiramycin | 0.25 | 0.25 | 0.25 | 0.25 |
| Ketolide | ||||
| Telithromycin | 0.03 | 0.03 | 0.03 | 0.03 |
| Lincosamides | ||||
| Lincomycin | 2 | 0.06 | 0.06 | 4 |
| Clindamycin | 1 | 0.03 | 0.03 | 2 |
| Streptogramins | ||||
| Quinupristin | 8 | 8 | 8 | 8 |
| Dalfopristin | 32 | 2 | 2 | >32 |
| Quinupristin-dalfopristin | 0.5 | 0.25 | 0.25 | 1 |
| Pleuromutilin | ||||
| Tiamulin | 1 | 0.12 | 0.12 | 32 |