FIG. 1.

NNRTI drug susceptibility conferred by N348I plus or minus M184V in B and non-B HIV-1 clinical isolates or molecular clones. Data are mean n-fold changes in drug EC₅₀s for mutant viruses compared to those for the wild-type virus across subtypes ± the standard error of the mean from two independent experiments. Statistical analyses using Student's t test compared subtype-specific N348I plus M184V mutant virus with N348I mutant virus. NS, no statistically significant difference. Black bars, N348I; grey bars, N348I plus M184V; white bars, M184V.